Stimulation by octanoate of insulin release from isolated rat pancreas.

Using pieces of rat pancreas incubated bation medium to 3.0 mg./ml. without in Krebs-bicarbonate buffer containing addition of octanoate produced a slight0.6 mg. glucose/ml., it has been found ly smaller though significant (p < .05) that addition of 3.0 mM. octanoate to increase in insulin release (2.96 t 0.96 the incubation medium significantly (p &J./mg.) above control levels. In con< .OOl) increased insulin release above clusion, octanoate is capable of directly control levels by 4.94 + 0.89 PU. insustimulating additional release of insulin lin/mg. of pancreatic tissue. Increasing by the beta-cells of the pancreas. (Methe glucose concentration in the incutabolism 16: No. 5, May, 482-484, 1967)